Miron Weinreb, D.M.D.
Department of Oral Biology
Professor and chairman,
Department of Oral Biology
Phone: 972-3-6406430
Fax: 972-3-6409250
E-mail:
This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Education
| 1976 |
D.M.D., Faculty of Dental Medicine, Hebrew University, Jerusalem |
| 1981-1983 |
Image processing, Computer Department, Hadassah School of Medicine, Hebrew University, Jerusalem
|
| 1986-1989 |
Post-Doctoral studies, Department of Bone Biology, Merck Sharp & Dohme Research Laboratories, Pennsylvania, USA
|
Academic and Professional Positions:
| 1974-1975 |
Research Assistant, Department of Anthropology, Anatomy and Embryology, Hadassah School of Medicine, Hebrew University, Jerusalem |
| 1976-1981 |
Dental Officer, Israel Defense Forces |
| 1981-1986 |
Research Fellow, Computer Department, Hadassah School of Medicine, Hebrew University, Jerusalem |
| 1983-1986 |
Instructor, Section of Occlusion, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 1986-1991 |
Lecturer in Periodontology, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 1991-1998 |
Senior Lecturer in Oral Biology, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 1998-2002 |
Chairman, D.M.D. Thesis Committee, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 1999-2000 |
President, the Israeli Division of the International Association of Dental Research (IADR) |
| 1999 |
Associate Professor in Oral Biology, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 2003 |
Acting Head, Department of Oral Biology, Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 2002-2007 |
Chairman, Research Committee, School of Dental Medicine, Tel-Aviv University, Tel-Aviv |
| 2004- |
Chairman, Department of Oral Biology, Goldschleger School of
Dental Medicine, Tel-Aviv University, Tel-Aviv |
Teaching:
- Course: Oral Histology for dental students (2nd year), School of Dental Medicine, Tel Aviv University.
- Course: Oral Biology for dental students (3rd year), School of Dental Medicine, Tel Aviv University.
- Course: Biological-Clinical correlations - seminar for dental students (6th year), School of Dental Medicine, Tel Aviv University.
Research Interest(s)
-
Bone regeneration and osteoprogenitor cells
-
Skeletal manifestations of various diseases
-
Prostaglandins as bone anabolic agents
Pub Med Articles: weinreb m
Selected publications:
M. Weinreb, D. Shinar, G.A. Rodan.
Different pattern of alkaline phosphatase, osteopontin and osteocalcin expression in developing rat bone visualized by in-situ hybridization.
Journal of Bone & Mineral Research 5(8):831-842, 1990.
D. Shinar,A. Schmidt, D. Halperin, G.A. Rodan, M. Weinreb.
Expression of av and b3 integrin subunits in rat osteoclasts in situ.
Journal of Bone and Mineral Research 8(4):403-414, 1993.
D.M. Shinar, N. Endo, D. Halperin, G.A. Rodan, M. Weinreb.
Differential expression of IGF-I and IGF-II mRNA in growing rat bone.
Endocrinology 132(3):1158-1167, 1993.
S. Keila, S. Pitaru, A. Grosskopf, M. Weinreb.
Bone marrow from mechanically unloaded rat bones expresses reduced osteogenic capacity in vitro. Journal of Bone and Mineral Research 9(3):321-327, 1994.
M. Weinreb, S.J. Rutledge, G.A. Rodan.
Systemic administration of an anabolic dose of Prostaglandin E2 induces early-response genes in rat bones.
Bone 20(4):347-353, 1997.
M. Weinreb, I. Suponitzki, S. Keila.
Systemic administration of an anabolic dose of PGE2 in young rats increases the osteogenic capacity of bone marrow.
Bone 20(6):521-526, 1997.
M. Weinreb and D. Halperin.
Rat osteoclast precursors in vivo express a vitronectin receptor and a chloride-bicarbonate exchanger.
Connective Tissue Research 37(3-4):177-182, 1998.
M. Weinreb, A. Grosskopf, N. Shir. The anabolic effect of PGE2 in rat bone marrow cultures is mediated via the EP4 receptor subtype.
American Journal of Physiology 276:E376-E383, 1999.
O. Segev, I. Chumakov I, Z. Nevo, D. Givol, L. Madar-Shapiro, Y. Sheinin, M. Weinreb, A. Yayon. Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3G380R transgenic mice.
Human Molecular Genetics 9(2): 249-258, 2000.
S. Keila, A. Kelner, M. Weinreb.
Systemic Prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro.
Journal of Endocrinology 168(1):131-139, 2001.
M. Weinreb, M. Machwate, N. Shir, M. Abramovitz, G.A. Rodan, S. Harada.
Expression of prostaglandin E2 (PGE2) receptor subtype EP4 and its regulation by PGE2 in osteoblastic cell lines and adult rat bone tissue.
Bone 28(3):275-281, 2001.
D. Shamir, S. Keila, M. Weinreb.
A selective EP4 receptor antagonist abrogates the stimulation of osteoblast recruitment from bone marrow stromal cells by PGE2 in vivo and in vitro.
Bone 34(1):157-162, 2004.
S. Keila, C. Nemcovsky, O. Moses, Z. Artzi, M. Weinreb.
In-Vitro effects of Enamel Matrix Proteins on rat bone marrow cells and gingival fibroblasts. Journal of Dental Research 83(2):134-138, 2004.
M. Weinreb, R. Dresner Pollak, Z. Ackerman.
Experimental cholestatic liver disease through bile-duct ligation (BDL) in rats results in skeletal fragility and impaired osteoblastogenesis.
Journal of Hepatology 40(3): 385-390, 2004.
R. Dresner-Pollak, N. Gelb, D. Rachmilewitz, F. Karmeli, M. Weinreb.
Interleukin 10 - deficient mice develop osteopenia, decreased bone formation and mechanical fragility of long bones.
Gastroenterology 127: 792-801, 2004.
M. Weinreb, D. Shamir, M. Machwate, G.A. Rodan, S. Harada, S. Keila.
PGE2 increases the number of rat bone marrow osteogenic stromal cells (BMSC) via binding the EP4 receptor, activating sphingosine kinase and inhibiting caspase activity.
Prostaglandins, Leukotrienes & Essential Fatty Acids 75(2):81-90, 2006.
E. Zeldich, R. Koren, C. Nemcovsky, M. Weinreb.
Enamel Matrix Derivative stimulates the proliferation of human gingival fibroblasts via ERK. Journal of Dental Research 86(1):41-46, 2007.
E. Zeldich , R. Koren, M. Dard, C. Nemcovsky, M. Weinreb.
Enamel Matrix Derivative protects human gingival fibroblasts from TNF- induced apoptosis by inhibiting caspase activation.
Journal of Cellular Physiology 213(3):750-758, 2007.
R. Dresner-Pollak, Y. Gabet, A. Steimatzky, G. Hamdani, I. Bab, Z. Ackerman, M. Weinreb. Human Parathyroid Hormone 1-34 prevents bone loss in experimental biliary cirrhosis in rats. Gastroenterology (in press).
|
